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Compelling preclinical and clinical research conducted at Georgetown University by KeifeRx’s co-founder, Charbel Moussa, MBBS, Ph.D., has demonstrated the ability of approved kinase inhibitor Nilotinib to cross the blood brain barrier in humans, enable toxic protein clearance, and show cognitive improvement in human trials.
The Science Behind KeifeRx
KeifeRx is building upon this extensive clinical experience in neurodegenerative diseases to advance a next generation of novel kinase Inhibitors that attack neurodegenerative diseases at their root cause. Our drugs candidates restore autophagy and attack the three pillars of neurodegenerative diseases; microglial-mediated neuroinflammation, toxic protein build up and vascular damage while restoring cognition.
Our lead asset is KFRX03, a first-in-class, small molecule kinase inhibitor for the treatment of Alzheimer’s disease that is highly brain penetrant with strong target engagement and a dose dependent PD/PK relationship. KFRX03 has a compelling safety profile with a strong therapeutic benefit in mice models of dementia.